There is a type of theory we can call a missing-pillars theory. A missing-pillars theory is a theory that lacks pillars of observation that should exist before the theory is asserted. To explain the idea, let me give a schematic diagram of a theory with a strong basis in observations:
Each one of the pillars is some observation that supports the theory. Here is an example. Imagine you are a prosecuting attorney, and your theory is that Johann Schmitzenkoler killed his wife by shooting her at her work. Observation Pillar #1 is a video showing the wife being fatally shot at work by a masked man the same height as the husband. Observation Pillar #2 is a witness saying Johann said he was going to kill his wife the day before the murder, to collect insurance money. Observation Pillar #3 is a video showing Johann approaching the wife's workplace just before the murder, and putting on a mask like the mask the killer wore. Observation Pillar #4 is that you found buried in Johann's garden a gun that the ballistics division says is the same gun that killed the wife.
A theory like the one just described is well-supported by evidence. But imagine a very different situation. Your theory is that Walter Willtowsky killed his wife Wilma. The wife has not been seen in a few days, but no one has found her body. In fact, it has not even been proven that the wife is dead. When Walter is questioned, he says that his wife is just visiting her mother, and will be back before long. You do not know any "when" involving the wife's murder. You do not know any "why" involving the wife's murder, and you do not know any "how" involving the wife's murder. In fact, you do not even know an "if" regarding the wife's murder, because you do not even know she is dead. In this case we have an example of a missing-pillars theory. The situation is illustrated below. Missing-pillars theories are like the two theories in the bottom row.

- Neuroscientists have microscopically examined many thousands of brains of the recently deceased, and also microscopically examined very much tissue recently removed from living people who had operations such as operations in which brain tissue was removed to reduce seizures. Such microscopic examination has often been done with microscopes which should have been powerful enough to find learned knowledge if it existed in human brains. But such microscopic examination has never discovered the slightest trace of learned information. By microscopic examination no one has ever found a single word someone learned or even a single letter or character stored in a brain. By microscopic examination no one has ever found a single image someone ever saw, and no one has ever found a single pixel of such an image.
- Neuroscientists lack any credible theory of how a brain could store a record of experiences someone had or how a brain could store something someone learned in school. When they are asked to discuss how such a thing could occur, neuroscientists merely engage in the vaguest hand-waving, such as muttering something about "synapse strengthening" (not a credible theory of how learned information could be stored in brains).
There seems to be no place in the brain suitable for storing memories that last for decades, and things like synapses and dendritic spines (alleged to be involved in memory storage) are unstable, "shifting sands" kind of things which do not last for years, and which consist of proteins that only last for weeks.
The synapses that transmit signals in the brain are very noisy and unreliable, in contrast to humans who can recall very large amounts of memorized information without error.
Signal transmission in the brain must mainly be a snail's pace affair, because of very serious slowing factors such as synaptic delays and synaptic fatigue (wrongly ignored by those who write about the speed of brain signals), and also the relatively slow transmission speed of dendrites, meaning brains are too slow to explain instantaneous human memory recall.
The brain seems to have no mechanism for reading memories.
The brain seems to have no mechanism for writing memories, nothing like the read-write heads found in computers.
The brain has nothing that might explain the instantaneous recall of long-ago-learned information that humans routinely display, and has nothing like the things that allow instant data retrieval in computers.
There is no sign that the brain or the human genome has any of the vast genomic apparatus it would need to have to accomplish the gigantic task of converting learned conceptual knowledge and episodic memories into neural states or synapse states (the task would presumably require thousands of specialized proteins, and there's no real sign that such memory-encoding proteins exist).
No neuroscientist has ever given a detailed explanation of how such a gigantic translation task of memory encoding could be accomplished (one that included precise, detailed examples).
Despite frequent misleading claims that the brain is like a computer, no one has ever discovered in a brain most of the things that are used by computers to compute. The brain has nothing like a CPU, nothing like an operating system, and nothing like software. No neural foundation has been discovered for human thinking abilities, and neuroscientists are unable to credibly examine how a human could think or reason.
Neuroscientists are so lacking in an explanation of how a brain could hold a belief or store an idea or principle or rule that there does not even exist a term used by neuroscientists to describe a belief or idea or principle or rule that is stored in a brain. There exists the word "engram" to describe the idea of a memory stored in the brain, but there does not exist a similar word to describe a belief or idea or principle or rule stored in a brain.
It is nowadays widely confessed by neuroscientists that they lack any neural explanation for the basic reality of consciousness or experience.
Neuroscientists lack any explanation for how the chemical and electrical activity of the brain could give rise to a strong experience of a single unified self, an experience that persists even when the two hemispheres of the brain fail to be joined by the connecting fibers of the corpus callosum, and even when such fibers are severed in operations to reduce seizures.
- It makes no sense to claim that you understand the origin of all species unless you understand in full the origin of the human species.
- It makes no sense to claim that you understand the origin of the human species unless you understand the origin of the human mind and all human mental capabilities.
- It makes no sense to claim that that you understand the origin of the human species unless you understand both the physical origin and the mental origin of individual human beings.
- It makes no sense to claim that that you understand the physical origin of an individual human being unless you can give a credible theory explaining the progression from a speck-sized zygote to a full adult body.
- It makes no sense to claim that that you understand the mental origin of an individual human being unless you can give a credible theory or theories explaining such phenomena as human self-hood, imagination, thinking, the phenomenon of instant learning, the phenomenon of the lifelong persistence of memories, and the phenomenon of the instant recall of detailed correct answers when someone is asked a question.
- It makes no sense to claim that that you understand the origin of all species unless you can credibly explain how there could have occurred a progression from one type of organism to some other type of organism with a vastly different structure and vastly different mental capabilities.
- It makes no sense to claim that you have some grand theory explaining the natural origin of all species if you cannot explain the origin of life itself; because if the origin of life requires a miracle or purposeful intervention, then "all bets are off" and miracles or purposeful intervention cannot be excluded elsewhere in the history of life.
- It makes no sense to claim that you have some grand theory explaining the natural origin of all species if you cannot explain a progression from microscopic life to macroscopic life in the form of large visible organisms.
- If makes no sense to claim that you have some grand theory explaining the natural origin of all species if you cannot explain basic matters of biology a million times simpler, such as how a eukaryotic cell is able to reproduce.
- There does not exist any credible theory explaining the natural origin of any very complex innovation in biology. Darwinism is no such theory, because it fails to credibly explain the vast leaps in organization and fine-tuned functional information needed for biological innovations. Such leaps cannot be explained by any gradualist theories, for reasons explained in my post "Anatomically Uninformative DNA, Nonfunctional Intermediates and Useless Early Stages Are Why Gradualism Does Not Work," which you can read here.
- There does not exist any credible theory explaining the natural origin of any complex anatomy innovation. The claim that such innovations are explained by random mutations in DNA is not tenable, largely because DNA does not specify the anatomy of any organism, contrary to the misstatements so often made by Darwinists. DNA only specifies low-level chemical information such as which amino acids make up a protein.
- There does not exist any credible theory explaining the natural origin of any type of very complex cell. The claim that such innovations are explained by random mutations in DNA is not tenable, largely because DNA does not specify the structure of any cell, and also does not specify the structure of any of the organelles that are the building components of cells.
- Far from being able to explain the origin of any cell type, biologists are unable to even explain the reproduction of any of the more complex cells in human bodies. The total number of well-arranged parts in a eukaryotic cell (the type of cell that humans have) is greater than or roughly the same as the total number of well-arranged parts in an automobile. Every time a typical eukaryotic cell reproduces, it is a marvel as hard-to-explain as an automobile splitting into two working automobiles.
- Scientists lack any credible explanation for the origin of new types of genes and new types of protein molecules. Requiring a very special arrangement of hundreds of amino acid parts (or a special arrangement of hundreds of nucleotide base pairs specifying such parts), the origin of a new type of gene or a new type of protein from accidental events is as unlikely as an ink splash producing a new paragraph of functional text that is well-written, well-spelled, useful and grammatical. One of the reasons why new types of genes and new types of protein molecules cannot be credibly explained by accidental natural processes is that they are both very sensitive to small changes and have very high functional thresholds, being non-functional in half-form. See my three posts marked "protein sensitivity" for a discussion of some of the scientific studies indicating that protein molecules are very sensitive to small changes.
- "A wide variety of protein structures exist in nature, however the evolutionary origins of this panoply of proteins remain unknown." -- Four Harvard scientists, "The role of evolutionary selection in the dynamics of protein structure evolution."
- "Tawfik admits the issue of a first protein is 'a complete mystery' because it reveals a paradox: enzymatic function depends upon the well-defined, three-dimensional structure of a protein scaffold, yet the 3D structure is too complex, too intricate, and too coordinated to arise without simpler precursors and intermediates....Tawfik soberly recognizes the problem. The appearance of early protein families, he has remarked, is 'something like close to a miracle.'....'In fact, to our knowledge,' Tawfik and Tóth-Petróczy write, 'no macromutations ... that gave birth to novel proteins have yet been identified.' " -- Tyler Hampton, quoting Dan S. Tawfik, professor in a Department of Biological Chemistry (link).
- "We have addressed a large body of evidence related to transitions (micro- and macro-) in proteins that have a pre-existing globular 3D-structure (and function), but how does structure and function evolve in de novo [new] proteins? ...Overall, the evolution of MIPSs, the recruitment of first enzymes, and de novo emergence of proteins are aspects where our knowledge is still at infancy -- Scientists confessing in 2022 that we don't know how new proteins originate (link).
- "The problem of protein folding is one of the most important problems of molecular biology. A central problem (the so called Levinthal's paradox) is that the protein is first synthesized as a linear molecule that must reach its native conformation in a short time (on the order of seconds or less). The protein can only perform its functions in this (often single) conformation. The problem, however, is that the number of possible conformational states is exponentially large for a long protein molecule. Despite almost 30 years of attempts to resolve this paradox, a solution has not yet been found." -- Two scientists, "On a generalized Levinthal's paradox," 2018.
- "The majority of cellular proteins function as subunits in larger protein complexes. However, very little is known about how protein complexes form in vivo." Duncan and Mata, "Widespread Cotranslational Formation of Protein Complexes," 2011.
- "While the occurrence of multiprotein assemblies is ubiquitous, the understanding of pathways that dictate the formation of quaternary structure remains enigmatic." -- Two scientists (link).
- "A general theoretical framework to understand protein complex formation and usage is still lacking." -- Two scientists, 2019 (link).
- "Comparative genome analyses indicate that every taxonomic group so far studied contains 10–20% of genes that lack recognizable homologs in other species...It is surprising that orphans have been completely ignored by most comparative genomics studies." -- Several scientists, "More than just orphans: are taxonomically-restricted genes important in evolution?"
- "Neo-Darwinism can't account for sexual reproduction." -- biologist Josh Mittledorf PhD, "Cracking the Aging Code," page 31.
- "It is not sufficient to postulate an amazing feat of mis-copying that contrived to produce a highly beneficial structural change. We have to postulate the simultaneous occurrence of three miracles. Whatever miracle occurs to a male, say, there must be the even greater miracle that just the same structural change occurs, by a chance mis-copying to a female, and furthermore, that the two miracles must happen in the same place at much the same time, otherwise the changed male will not find the changed female. Mathematically, this means that the probability of an appreciable change being successfully propagated is the product of these three small numbers, making the result negligibly small." -- Scientist Fred Hoyle (link).
- "Replication [of cells] is one of the deepest mysteries of biology. It is really something totally counterintuitive if cell is seen as a sack of water plus some chemicals. We have a lot [of] facts about what happens in the replication at DNA level but how this miracle happens is a mystery. At cell level the situation gets even more complex." -- M. Pitkanen, physics PhD, "Getting philosophical: some comments about the problems of physics, neuroscience, and biology."
- "How cells control their size and maintain stable size distributions is one of the most fundamental, unsolved problems in biology...Even for the bacterium E. coli, arguably the most extensively studied organism to date, no one has been able to answer this question." --Suckjoon Jun, an assistant professor of physics and molecular biology (link).
- "Cell biology is a mystery for many reasons oneof which is the lack of basic knowledge. This maybe the fault of scientists or simply a failure in basicinformation at the level of common contemporaryknowledge. The well known sentence of Socrates:'I know that I know nothing' is as true in cellbiology as in other scientific fields. This sentencewas modified by Lloyd in 1986 who claimed: 'Thecloser we look, the less we see'. I would like tomodify this sentence yet again as a cell biologist andmicroscopist: 'The closer we look, the less we knowabout.' ... Everyone involved in cellbiology, is surprised how limited is our knowledgeabout the various cell compartments....It should now be mentioned that our knowledge even of basic cell organelles, including their various functions, is very limited....We know something about cell organelles, including various nuclear compartments, but most of their functions are waiting for further and better clarification....Depending on conditions, selected genes may be repressed or derepressed and activated giving to rise to the particular cell lineage with characteristic cell structures and functions. On the other hand, such transformations, including the homing of the transformed cells are also very mysterious although both these processes are empirically used in clinical medicine." Karel Smetana, cell biologist, "To the Mystery of Cell Biology.," (link).
- "Despite the centrality of multicellularity and cell differentiation to animal biology, their origins are little understood." -- Two cell biologists (link).
- "Protein assemblies are at the basis of numerous biological machines by performing actions that none of the individual proteins would be able to do. There are thousands, perhaps millions of different types and states of proteins in a living organism, and the number of possible interactions between them is enormous...The strong synergy within the protein complex makes it irreducible to an incremental process. They are rather to be acknowledged as fine-tuned initial conditions of the constituting protein sequences. These structures are biological examples of nano-engineering that surpass anything human engineers have created. Such systems pose a serious challenge to a Darwinian account of evolution, since irreducibly complex systems have no direct series of selectable intermediates, and in addition, as we saw in Section 4.1, each module (protein) is of low probability by itself." -- Steinar Thorvaldsen and Ola Hössjerm, "Using statistical methods to model the fine-tuning of molecular machines and systems," Journal of Theoretical Biology.
- "The greatest twentieth century paleontologist, George Gaylord Simpson, in midcentury had to admit to a reality of the fossil record: 'It remains true, as every paleontologist knows, that most new species, genera, and families, and that nearly all new categories above the level of families, appear in the record suddenly, and are not led up to by known, gradual, completely continuous transitional sequences.' " --"Lamarck's Revenge” by paleontologist Peter Ward , page 43.
- "The first eye, the first wing, the first placenta. How they emerge. Explaining these is the foundational motivation of evolutionary biology. And yet, we still do not have a good answer. This classic idea of gradual change, one happy accident at a time, has so far fallen flat.” -- Biologist Armin Moczek.
- "Considering that the total number of known fossil species is nearly one hundred thousand, the fact that the only relatively convincing morphological sequences are a handful of cases like the horse, which do not involve a great deal of change, and which in many cases like the elephant may not even represent phylogenetic sequences at all, serves to emphasize the remarkable lack of any direct evidence for major evolutionary transformations in the fossil record." -- Michael Denton, MD and biochemistry PhD, "Evolution: A Theory in Crisis," 1986, page 185.
- "Major transitions in biological evolution show the same pattern of sudden emergence of diverse forms at a new level of complexity. The relationships between major groups within an emergent new class of biological entities are hard to decipher and do not seem to fit the tree pattern that, following Darwin's original proposal, remains the dominant description of biological evolution. The cases in point include the origin of complex RNA molecules and protein folds; major groups of viruses; archaea and bacteria, and the principal lineages within each of these prokaryotic domains; eukaryotic supergroups; and animal phyla. In each of these pivotal nexuses in life's history, the principal 'types' seem to appear rapidly and fully equipped with the signature features of the respective new level of biological organization. No intermediate 'grades' or intermediate forms between different types are detectable." -- Biologist Eugene Koonin, "The Biological Big Bang model for the major transitions in evolution" (link).
- "This is the basic story of evolution, as recounted in countless textbooks and pop-science bestsellers. The problem, according to a growing number of scientists, is that it is absurdly crude and misleading." --Stephen Buranyi, science writer, "Do We Need a New Theory of Evolution?" in The Guardian.
- "I may challenge the adherents of the strictly Darwinian view, which we are discussing here, to try to explain the evolution of the following features by accumulation and selection of small mutants: hair in mammals, feathers in birds, segmentation of arthropods and vertebrates, the transformation of gill arches in phylogeny, including the aortic arches, muscles, nerves, etc.; further, teeth, shells of mollusks, ectoskeletons, compound eyes, blood circulation, alternation of generations, statocysts, ambulacral system of echinoderms, pedicellaria of the same, cnidocysts, poison apparatus of snakes, whalebone, and, finally, primary chemical differences like hemoglobin vs. hemocyanin, etc. Corresponding examples from plants could be given." -- Biologist Richard Goldschmidt, "The Material Basis of Evolution," pages 6-7.
- “While scientists are still working out the details of how the eye evolved, we are also still stuck on the question of how intelligence emerges in biology.” -- Scientists Rafael Yuste and Michael Levin, an article in Scientific American.
- "Biological systems have evolved to amazingly complex states, yet we do not understand in general how evolution operates to generate increasing genetic and functional complexity." -- four scientists, "Adaptive ratchets and the evolution of molecular complexity."
- "I should like to critically object that this model has not been supported by an affirmative estimate of probabilities so far. Such an estimate of the theoretical time scale of evolution as implied by the model should be compared with the empirical time scale. One would need to show that, according to the assumed model, the probability of de facto existing purposeful features to evolve was sufficiently high on the empirically known time scale. Such an estimate has nowhere been attempted though." -- Eminent physicist Wolfgang von Pauli, discoverer of the biologically crucial Pauli Exclusion Principle (link).
- "Until reading an able and valuable article in the North British Review (June, 1867), I did not appreciate how rarely single variations, whether slight or strongly marked, could be perpetuated." -- Charles Darwin (link).
- "The higher the organization, whether of an entire organism or of a single organ, the greater is the number of the parts that cooperate, and the more perfect is their cooperation ; and consequently, the more necessity there is for corresponding variations to take place in all the cooperating parts at once, and the more useless will be any variation whatever unless it is accompanied by corresponding variations in the cooperating parts; while it is obvious that the greater the number of variations which are needed in order to effect an improvement, the less will be the probability of their all occurring at once....There are improbabilities so great that the common-sense of mankind treats them as impossibilities. It is not, for instance, in the strictest sense of the word, impossible that a poem and a mathematical proposition should be obtained by the process of shaking letters out of a box ; but it is improbable to a degree that cannot be distinguished from impossibility ; and the improbability of obtaining an improvement in an organ by means of several spontaneous variations, all occurring together, is an improbability of the same kind." -- Joseph John Murphy, biology scholar, author of a massive biology tome (link).
- "What gambler would be crazy enough to play roulette with random evolution? The probability of dust carried by the wind reproducing Durer's 'Melancholia' is less infinitesimal than the probability of copy errors in the DNA molecule leading to the formation of the eye...There is no law against daydreaming, but science must not indulge in it." -- Biologist Pierre-Paul Grasse (link).
- "Natural selection acting on populations is incapable of guiding evolution." -- Biologist Pierre-Paul Grasse (link).
- "Big picture, we want to understand how initially dumb clumps of cells, cells that are one or two mutations away from being single-celled, don’t really know that they’re organisms — they don’t have any adaptations to being multicellular, they’re just a dumb clump — how those dumb clumps of cells can evolve into increasingly complex multicellular organisms, with new morphologies, with cell-level integration, division of labor, and differentiation amongst the cells. Just like, we want to watch that process of how do these simple groups become complex. And this is, like, one of the biggest knowledge gaps in evolutionary biology. I mean, in my opinion.....We don’t really know the process through which simple groups evolve into increasingly complex organisms."-- Biologist Will Ratcliff (link).
- "How animals evolved complex multicellularity from their unicellular ancestors remains unanswered." -- A 2026 paper by several scientists (link).
- "The evolutionary divergence of a single species into two has never been directly observed in nature, primarily because speciation can take a longtime to occur." -- Irwin, Bensch, and Price, "Speciation in a Ring," Nature, 2001.
- "Genetics might be adequate for explaining microevolution, but micro-evolutionary changes in gene frequency were not seen as able to turn a reptile into a mammal or to convert a fish into an amphibian. Microevolution looks at adaptations that concern only the survival of the fittest, not the arrival of the fittest. As Goodwin (1995) points out, 'the origin of species — Darwin's problem — remains unsolved." "Resynthesizing Evolutionary and Developmental Biology," Gilbert, Opitz and Raft, 1996.




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