When I read a previous article written by science writer Phillip Ball at Quanta Magazine, an article on DNA, I felt like writing a post in response that would be entitled "Pondering DNA, Phillip Ball Drops the Ball" (a reference to fumbling). Phillip Ball is a writer who has figured out that the long-told story about DNA and its genes simply isn't true. But he seems to have completely failed to realize the enormous implications of such a thing.
As an explanation for how human bodies arise, "DNA as body blueprint" was always a childish myth, both because DNA has neither any body blueprint nor any cell blueprint, and also because blueprints have no power to build things (as explained below).
Not long after DNA was discovered about the middle of the twentieth century, scientists and science writers began spreading a false idea about DNA: the idea that DNA contains a specification for building an organism such as a human. There are various ways in which this false idea is stated, all equally false:
- Many described DNA or the genome as a blueprint for an organism.
- Many said DNA or the genome is a recipe for making an organism.
- Many said DNA or the genome is a program for building an organism, making an analogy to a computer program.
- Many claimed that DNA or genomes specify the anatomy of an organism.
- Many claimed that genotypes (the DNA in organisms) specify phenotypes (the observable characteristics of an organism), or that the genotype is a "map" of the phenotype.
- Many claimed that phenotypes (the observable characteristics of an organism) are "expressions" of genotypes (the DNA in organisms).
- Many claimed that genotypes (the DNA in organisms) "map" phenotypes (the observable characteristics of an organism) or "map to" phenotypes.
- Many claimed that DNA contains "all the instructions needed to make an organism."
- Many claimed that there is a "genetic architecture" for an organism's body or some fraction of that body.
- Many claimed that DNA or its genes "guide," "direct" or "control" the nine-month process by which a zygote progresses to become a full-sized human baby.
- Using a little equation, many claimed that a "genotype plus the environment equals the phenotype," a formulation as false as the preceding statements, since we know of nothing in the environment that would cause phenotypes to arise from genotypes that do not specify such phenotypes.
- Scientists Walker and Davies state this in a scientific paper: "DNA is not a blueprint for an organism; no information is actively processed by DNA alone...DNA is a passive repository for transcription of stored data into RNA, some (but by no means all) of which goes on to be translated into proteins."
- Geneticist Adam Rutherford states that "DNA is not a blueprint," a statement also made by biochemistry professor Keith Fox.
- "The genome is not a blueprint," says Kevin Mitchell, a geneticist and neuroscientist at Trinity College Dublin, noting "it doesn't encode some specific outcome."
- "DNA cannot be seen as the 'blueprint' for life," says Antony Jose, associate professor of cell biology and molecular genetics at the University of Maryland, who says, "It is at best an overlapping and potentially scrambled list of ingredients that is used differently by different cells at different times."
- "The majority of cellular proteins function as subunits in larger protein complexes. However, very little is known about how protein complexes form in vivo." Duncan and Mata, "Widespread Cotranslational Formation of Protein Complexes," 2011.
- "A general theoretical framework to understand protein complex formation and usage is still lacking." -- Two scientists, 2019 (link).
- "The problem of protein folding is one of the most important problems of molecular biology. A central problem (the so called Levinthal's paradox) is that the protein is first synthesized as a linear molecule that must reach its native conformation in a short time (on the order of seconds or less). The protein can only perform its functions in this (often single) conformation. The problem, however, is that the number of possible conformational states is exponentially large for a long protein molecule. Despite almost 30 years of attempts to resolve this paradox, a solution has not yet been found." -- Two scientists, "On a generalized Levinthal's paradox," 2018.
- "How proteins fold remains a central unsolved problem in biology. While the idea of a folding code embedded in the amino acid sequence was introduced more than 6 decades ago, this code remains undefined. While we now have powerful predictive tools to predict the final native structure of proteins, we still lack a predictive framework for how [amino acid] sequences dictate folding pathways....Almost seven decades of experimental and theoretical inquiry have not revealed a 'folding code' at the amino acid level, i.e., rules endowed with the generality and predictive power required to connect amino acid sequence to how the protein attains its structure....Machine learning made it possible to identify weak correlations to generate the structure most likely to correspond to a sequence. This tour-de-force effort has largely solved the problem of predicting protein structure from sequence...but with a key limitation: the algorithm that predicts the structure is a complex black box of pattern recognition that casts little light on the process of folding and that tells us nothing about why only some sequences fold, or how physics and evolution are coupled." -- Five scientists in the year 2025 (link).
- "The real challenge—that remains unanswered after more than 50 years of research in the structural biology field—is understanding the mechanisms that lead proteins to fold into their native state. The reason for these difficulties is that the central question of the protein folding problem remains unresolved: specifically, how a sequence of amino acids encodes its folding pathways." -- Scientist Jorge A. Vila, 2025 (link).
- "Yet while these are several examples of well-understood processes, our study of animal morphogenesis is really in its infancy." -- David Bilder and Saori L. Haigo1, "Expanding the Morphogenetic Repertoire: Perspectives from the Drosophila Egg."
- "Fundamentally, we have a poor understanding of how any internal organ forms." -- Timothy Saunders, developmental biologist (link).
- "An adult human body is made up of some 30 to 40 trillion cells, all of which stem from a single fertilized egg cell. The process by which the right cells appear to arrive in their right numbers at the right time at the right place -- development -- is only understood in the roughest of outlines." -- Five scientists (link).
- "Our understanding of how our organs form is still in its infancy" -- A research project abstract written by scientists (link).
- "Biochemistry cannot provide the spatial information needed to explain morphogenesis...Supracellular morphogenesis is mysterious...Nobody seems to understand the origin of biological and cellular order." -- Six medical authorities (link). "
- "Understanding the rules underlying organismal development is a major unsolved problem in biology. Each cell in a developing organism responds to signals in its local environment by dividing, excreting, consuming, or reorganizing, yet how these individual actions coordinate over a macroscopic number of cells to grow complex structures with exquisite functionality is unknown." - Five scientists (link).
- "However, our understanding of the molecular and physical basis of morphogenesis in plants or in any other eukaryotic system [e.g. mammals] is still in its infancy due to the complexity and non-linearity of processes involved in morphogenesis dynamics (or Morphodynamics)." -- A description of a 2017-2021 scientific project, presumably written by scientists (link).
- "Understanding morphogenesis in vertebrate tissues in development and disease poses one of the most significant challenges in the life sciences. Despite the impressive technical advances aimed at cellular and subcellular characterization and manipulation over the past half century, a clear picture of how form is created still remains in its infancy." -- Four scientists in 2025 (link).
- "We don't know what dark matter is, we don't understand how the brain works or consciousness, we don't understand morphogenesis, we don't understand the origin of life." -- Physics PhD Michael Nielsen (link).
















