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Our future, our universe, and other weighty topics

Sunday, June 30, 2019

So Many Better Arguments Against Materialism Than the One He Uses

At the Aeon web site, we recently had an essay entitled “Minding Matter.” Under that title we read a subtitle or “teaser text” that reads, “The closer you look, the more the materialist position in physics seems to rest on shaky metaphysical ground.” Materialism is actually a position in philosophy rather than physics. Materialism is the claim that matter or mass-energy is all that exists, and according to such a position your mind is purely a product of your brain (or perhaps just an aspect of your brain).

I was interested in what argument or arguments the author (the astrophysicist Adam Frank) would present against materialism. But the only argument Frank gave was one of the weakest arguments anyone could use against materialist claims about the mind. It was an argument that can be summarized like this: “We can't be sure that minds are produced by matter (or that minds are just some aspect of matter), because we're not really sure what matter is.”

Frank discusses at some length the fact that while nineteenth century scientists regarded atoms as being solid little balls of matter, we now know that atoms are made of smaller particles such as electrons, protons and neutrons; and a particle such as an electron has a kind of “fuzzy” nature , so we can't be sure exactly what it is. This is partially because of quantum mechanics, the modern theory of subatomic reality. There are different interpretations of quantum mechanics that disagree with each other, so we cannot be sure of the exact nature of matter on the lowest level. Frank states this: We know that matter remains mysterious just as mind remains mysterious, and we don’t know what the connections between those mysteries should be."

This is one of the weakest arguments I can imagine against the materialist claim that brains make minds or that minds are just an aspect of brains. The argument does nothing to provide evidence against such a claim, but merely raises a kind of weak question mark suggesting that maybe such a claim isn't certain.

The weakness of Frank's argument can be shown by the fact that what he mentions can be used (with equally weak force) in a way exactly opposite to the way he has used it. For example, a materialist could argue like this:

Now, it may seem impossible to believe that matter could produce minds if matter consists of hard solid atoms that are like little billiard balls. But quantum mechanics clouds the waters. For example, we don't really know what an electron is. Since we don't really have understanding at the lowest level of what matter is, who is to say that it could not be producing mind?”

If Frank had actually wanted to argue against the claim that minds are merely the product of brains, or an aspect of brains, there are many arguments that he could have used far stronger than the “weak tea” argument he has used. Such arguments are presented in my blog site www.headtruth.blogspot.com. Below are some of these arguments, but not all of them:

  1. As shown in the many examples given here, here, here, here and here, contrary to the predictions of materialism, human minds can operate very well despite tremendous damage to the brain, caused by injury, disease or surgery. For example, removing half of a person's brain in the operation known as hemispherectomy produces little change in memory or cognitive abilities. There have been quite a few cases of people (such as Lorber's patients) who were able to think and speak very well despite having lost more than 60% of their brain due to disease. Such cases argue powerfully that the human mind is not actually a product of the brain or an aspect of the brain.
  2. Although it is claimed that memories are stored in the brain (specifically in synapses), there is no place in the brain that is a plausible storage site for human memories that can last for 50 years or longer. The proteins that make up both synapses and dendritic spines are quite short-lived, being subject to very high molecular turnover which gives them an average lifetime of only a few weeks. Both synapses and dendritic spines are a “shifting sands” substrate absolutely unsuitable for storing memories that last reliably for decades.
  3. It is claimed that memories are stored in brains, but humans are able to instantly recall accurately very obscure items of knowledge and memories learned or experienced decades ago; and the brain seems to have none of the characteristics that would allow such a thing. The recall of an obscure memory from a brain would require some ability to access the exact location in the brain where such a memory was stored (such as the neurons near neuron# 8,124,412,242). But given the lack of any neuron coordinate system or any neuron position notation system or anything like an indexing system or addressing system in the brain, it would seem impossible for a brain to perform anything like such an instantaneous lookup of stored information from some exact spot in the brain.
  4. If humans were storing their memories in brains, there would have to be a fantastically complex translation system (almost infinitely more complicated than the ASCII code or the genetic code) by which mental concepts, words and images are translated into neural states. But no trace of any such system has ever been found, no one has given a credible detailed theory of how it could work, and if it existed it would be a “miracle of design” that would be naturally inexplicable.
  5. Contrary to claims that minds are merely an aspect of brains or a product of brains, we know from near-death experiences that human minds can continue to operate even after hearts have stopped and brains have shut down. As discussed here, such experiences often include observations of hospital details or medical details that should have been impossible if a mere hallucination was the cause of the experience.
  6. If human brains actually stored conceptual and experiential memories, the human brain would have to have both a write mechanism by which exact information can be precisely written, and a read mechanism by which exact information can be precisely read. The brain seems to have neither of these things. There is nothing in the brain similar to the “read-write” heads found in computers.
  7. We understand how physical things can produce physical effects (such as an asteroid producing a crater), and how mental things can produce mental effects (such as how a belief can give rise to another belief or an emotion). But no one has the slightest idea how a physical thing could ever produce a mental effect. As discussed here, no one has any understanding of how a brain or neurons in a brain could produce anything like a thought or an idea.
  8. We know from our experience with computers the type of things that an information storage and retrieval system uses and requires. The human brain seems to have nothing like any of these things
  9. As discussed here, humans can form new memories instantly, at a speed much faster than would be possible if we were using our brains to store such memories. It is typically claimed that memories are stored by “synapse strengthening” and protein synthesis, but such things do not work fast enough to explain the formation of memories that can occur instantly.
  10. As discussed here, human brains do not show signs of working harder during thinking or memory recall, contrary to what we would expect if such effects were being produced by brains.
  11. Contrary to the idea that human memories are stored in synapses, the density of synapses sharply decreases between childhood and early adulthood. We see no neural effect matching the growth of learned memories in human.
  12. There are many humans with either exceptional memory abilities (such as those with hyperthymesia who can recall every day of their adulthood) or exceptional thinking abilities (such as savants with incredible calculation abilities). But such cases do not involve larger brains, very often involve completely ordinary brains, and quite often involve damaged brains, quite to the contrary of what we would expect from the “brains make minds” assumption.
  13. The very strong laboratory evidence for psi (most notably extrasensory perception) shows that humans have abilities that cannot be explained by neural activity, and that must involve some higher consciousness reality beyond the brain.
  14. Results from the animal kingdom are inconsistent with claim that minds are made from brains and memories stored in brains. For example, animals such as crows with very small brains (and no cerebral cortex) perform astonishingly well on mental tests; elephants with brains four times larger than ours are not nearly as smart as us; and flatworms that have been taught things and then decapitated can still remember what they learned, after regrowing a head.
  15. Well-documented evidence for apparitions provides evidence that the human mind is not merely the result of brain activity. Such evidence includes (1) more than 100 cases of people who saw an apparition of someone they did not know had died, only to very soon learn that the corresponding person had died (as discussed here, here, here and here); (2) many additional cases of apparitions seen by multiple observers, contrary to the explanation of hallucination (discussed here and here); (3) many other cases of death-bed apparitions as discussed here and documented by researchers such as Haraldsson and Osis
  16. Contrary to claims that the brain is the source of human thinking and memory recall, a full analysis of the signal delaying factors in the human brain (such as synaptic delays and synaptic fatigue) shows that signals in the brain cannot be traveling fast enough to explain human thinking and human memory recall which can occur instantaneously.
  17.  The human brain experiences extremely severe levels of signal noise, so much signal noise that we should not believe that it is the brain that is producing human memory recall that can occur massively and flawlessly for people such as Hamlet actors and Wagnerian tenors. 
These things all indicate that our minds and memory (or paranormal phenomena) must be the result of some spiritual or immaterial aspect of man or some soul aspect of man, in direct contradiction to the position of materialism that such a thing does not exist. 


Postscript: Discussing hemispherectomy operations in which half of a brain is removed to stop seizures, the paper here states,  "Others, (Ogden, 1988; Riva & Gazzaniga, 1986; Vargha-Khadem et al., 1997a; Verity, 1982) have reported excellent, even normal linguistic abilities after hemispherectomy of either side" of the brain. An interesting scientific paper is entitled, "When only the right hemisphere is left: Studies in language and communication." The study gives us an in-depth analysis of a subject named BL who as a child had half of his brain removed (the left half) in a hemispherectomy operation to reduce seizures.  The paper tells us that BL has "above normal intelligence" and that he graduated from college with a bachelor's degree in business and sociology.  In a battery of tests of memory and language, the subject showed normal results, with only slight, subtle defecits. He scored above-average on a few memory-related tests, such as the Boston Naming Test and the Famous Names and Faces test.  We are told, "Regarding speech, language, and communicative function, BL's performance appears grossly normal in pronunciation, grammar, semantics, and usage." 

A study such as this helps to debunk dogmas such as the dogma that the brain is the source of our minds.  You can read about many similar cases by following the links above.  Referring to patients who had half of their brains removed in hemispherectomy operations, the paper states, "The numerous observations on cognitively intact persons hemispherectomized in childhood bring to mind the report of Lorber (1983) on hydrocephalic adults, whose brains are constituted of only a thin layer of cerebral tissue, and yet who enjoy normal or superior motor and cognitive abilities." Talking about the small effect of hemispherectomy operations in which half of a brain is removed, a doctor states, "When you take out half of their brain in one sitting it’s as if they weren’t touched." When will our neuroscientists start putting two and two together to reach the conclusion that is taught by such observational facts? 

Thursday, June 27, 2019

New Study Indicates Why DMT Can't Explain Near-Death Experiences

Ever since Raymond Moody's best-selling 1975 book Life after Life, the common characteristics of a near-death experience have been well-known. A particular near-death experience may have between one or more of these characteristics. The characteristics include:

  • a sensation of floating out of the body, which may include seeming to view the body from above;
  • feelings of peace, joy or tranquility;
  • a life-review in which previous life events are reviewed or relived in some sped-up manner;
  • a passage through a tunnel;
  • an encounter with a very bright light or a “being of light” or a light that is somehow sensed to be numinous or a source of thought or feeling;
  • an experience of seeing some heavenly or supernatural realm;
  • an experience of seeming to see one or more deceased relatives;
  • an experience of being told that you must “go back” and continue to live your regular life;
  • an experience of having heightened consciousness, mentality or perception.

Since near-death experiences were first reported, those who do not believe in a soul or life after death have been trying to suggest a natural explanation for the phenomenon.  One attempt at an explanation is what we may call the "stash release" theory. This is the idea that when someone is at the verge of death or undergoing a cardiac arrest, there can be a release of hallucinogenic chemicals stored in the brain.  A person may try to back up this claim by saying something like "DMT has been detected in the brain of mammals." However, there has never existed any evidence that any hallucinogenic chemicals exist in the brain of mammals other than in micro-traces a thousand times too small to produce a hallucination.  

There's a new study on the topic published in a scientific journal. It is remarkable how the press release on this topic (and the NeuroscienceNews.com story based on the press release) misleadingly describe the study as if it were something supporting the "stash release" theory. The headline on NeuroscienceNews.com is " ‘Mystical’ psychedelic compound found in normal brains."  The story tells us that DMT has been discovered in mammalian brains. It also says, "Her team’s work has also revealed that the levels of DMT increase in some rats experiencing cardiac arrest." But no mention is made in the story of what level of DMT was found in a mammalian brain, and no mention is made by how much the DMT level increased during cardiac arrest. You should tend to be suspicious of scientific news stories that fail to provide the relevant numbers. 

Luckily the story is based on a study in a scientific journal, and the whole study can be read online here.  Deplorably, the study does not reveal in its abstract what level of DMT was measured.  But if you dive into the study we can get that information. The level of DMT detected was about 1 nanomole, a billionth of a mole. The paper states, "the normal rat brain contained detectable levels of DMT..ranging 0.05–1.8 nM with an average of 0.56 nM." The abbreviation nM stands for nanomole. So the study tells us that a rat brain has only about 1 nanomole of DMT.

How much is a nanomole?  It's about 300,000 times smaller than the amount needed to produce a hallucinogenic result. The dose typically used to produce DMT hallucinations or a DMT "trip" is about 30 milligrams.  That's a dose about 300,000 times stronger than a nanomole.  

According to the site here, which can be used as a rough guide, 5750 milligrams of a particular substance is equivalent to .05 moles. So an amount 100 times smaller (about 57 milligrams) would be equal to about .0005 moles. We multiply that .0005 by a billion to get the equivalent number of nanomoles, leaving us with 500,000.  So a dose of 57 milligrams is about 500,000 nanomoles, a dose of 30 milligrams is about 300,000 nanomoles, and a single nanomole is only about 1/300,000 of the minimum 30 milligrams to produce a hallucinogenic result. 

As for the claimed cardiac arrest increase in DMT, the paper shows that it is only an increase from 1 nanomole to 2 nanomoles. That means that even during cardiac arrest, the DMT would still be 150,000 times too small to produce a hallucinogenic result. 

The news article written about the study failed to make any mention of the fact that mere nano-traces of DMT had been measured.  This is not quite chicanery and deceit. It is also not quite chicanery and deceit for a man to vaguely tell his girlfriend, "I have accumulated some savings," when these savings consist merely of one penny deposited each month into a piggy bank. 

See the post here for why there is a huge difference between DMT experiences and near-death experiences, and why DMT could not actually explain near-death experiences, even if it existed in the brain a million times greater than the nano-traces that have been detected. 

A DMT trip is a little like this

Postscript: There's a new study indicating that near-death experiences are astonishingly common. The study is entitled “Prevalence of near-death experiences and REM sleep intrusion in 1034 adults from 35 countries.” Using a “crowdsourcing” platform to get a random sample of 1034 adults from many different countries, the study authors found that 28% of the respondents answered “Yes” when asked whether they had ever had a near-death experience.

This 28% was then asked to answer “Yes” or “No” to the following questions (called “Greyson scale questions”):

• Did time seem to speed up or slow down?
• Were your thoughts speeded up?
• Did scenes from your past come back to you?
• Did you suddenly seem to understand everything?
• Did you have a feeling of peace or pleasantness? *
• Did you have a feeling of joy?
• Did you feel a sense of harmony or unity with the universe?
• Did you see, or feel surrounded by, a brilliant light?
• Were your senses more vivid than usual?
• Did you seem to be aware of things going on elsewhere, as if by extrasensory perception or telepathy?
• Did scenes from the future come to you?
• Did you feel separated from your body?
• Did you seem to enter some other, unearthly world?
• Did you seem to encounter a mystical being or presence or hear an unidentifiable voice?
• Did you see deceased or religious spirits?
• Did you come to a border or point of no return?

Only those who answered “Yes” to 7 or more of these questions were judged to have had a “full-scale” near-death experience. Ten percent of the respondents answered “Yes” to 7 or more of these questions.

You may realize how remarkable such a result is when you consider that only a small fraction of the population have ever come close to death. There are no exact figures on what percentage of the population has come close to death, but a reasonable ballpark estimate might be between 10% and 20%. So it seems like a very high fraction of those who come to death experience near-death experiences.

The scientific paper tries to suggest some causal relation between what is called “REM sleep intrusion” and near-death experiences. REM sleep intrusion is supposedly some state in which someone can briefly dream while he is awake. To try to determine the level of “REM sleep intrusion” in respondents, the scientific survey asked these questions:
  • Just before falling asleep or just after awakening, have you ever seen objects, things or people that others can’t see?
  • Just before falling asleep or just after awakening, have you ever heard voices, music or sounds that other people can’t hear?
  • Have you ever awakened and felt paralyzed or found that you were unable to move?
  • Have you ever had abrupt muscle weakness in your legs or knee buckling, or felt sudden muscle weakness in your face or head drop?

Twenty percent of the overall respondents answered “Yes” to three or more of these four questions, but 34% of those who claimed to have a near-death experience answered “Yes” to three or more of these questions. 47% of those who were judged to have had “full-scale” near-death experiences answered “Yes” to three or more of these “REM sleep intrusion” questions.

The authors have tried to play this up as something significant, but it may have no causal significance at all. We can easily explain the difference without imagining any causal relation between “REM sleep intrusion” and near-death experiences.

The “REM sleep intrusion” questions are questions about abnormal experiences. Anyone answering the survey and reporting a near-death experience might simply be someone more prone to candidly admit to an abnormal experience.

In many ways we are socially conditioned not to report abnormal experiences, for fear of being ridiculed as an oddball. But if a person has already admitted in a survey that he has had one type of abnormal experience (a near-death experience), he may then be much more likely to admit another type of abnormal experience involving sleeping. This greater tendency to confess to a second abnormal experience (after confessing to a first abnormal experience) can easily explain the somewhat greater “REM sleep intrusion” scores of people who experienced near-death experiences.

The page here briefly explains why “REM sleep intrusion” is not a credible explanation for near-death experiences, and the paper here explains such a thing in much greater length.

Monday, June 24, 2019

Eerie Skies: A Science Fiction Story

In the year 2031 a strange series of events caused more and more people to wonder whether planet Earth was receiving visitors from another planet. It began in April with the appearance of crop circles all over the world. The mysterious crop circles were reported in more than 50 different fields in 20 countries. Often more than 100 meters in size, the strange crop circles would appear overnight, and had incredibly intricate geometric patterns.

The press reported on the phenomenon. But for balance the press also asked the chairman of the Committee for Total Skepticism about the strange crop circles.

“This is just two guys with a board and a rope making the crop circles,” said the committee chairman, Paul Davidson.

“Precisely,” said the committee's vice-chairman, William Carter.

But the next month there was a strange new phenomenon. People across the world reported balls of light floating about at street level. The balls of light would often enter into people's homes. Some thought that the balls of light were some kind of reconnaissance devices to gather intelligence about the way humans lived.

The press reported on the phenomenon. But for balance the press also asked the chairman of the Committee for Total Skepticism about the strange balls of light.

“There is a mundane natural explanation,” said the committee chairman, Paul Davidson. “It's just ball lightning.”

“Precisely,” said the committee's vice-chairman, William Carter.

In June there was another alarming development. Huge UFOs were seen in fifty places all over the world. They were sometimes seen moving at incredible speeds.

The press reported on the phenomenon. But for balance the press also asked the chairman of the Committee for Total Skepticism about the huge UFOs.

“There is a mundane natural explanation,” said the committee chairman, Paul Davidson. “It's just swamp gas.”

“Precisely,” said the committee's vice-chairman, William Carter. “Accelerating swamp gas.”

The next month at an outdoor rock concert 70,000 people reported seeing directly above them a giant UFO the size of an aircraft carrier. The witnesses claimed that they could look inside windows of the giant flying craft, and see strange creatures moving around.

The press reported on the strange sighting. But for balance the press also asked the chairman of the Committee for Total Skepticism about the huge UFO.

“There is a simple natural explanation,” said the committee chairman, Paul Davidson. “The report was just a case of mass hysteria.”

“Precisely,” said the committee's vice-chairman, William Carter. “Social-media-facilitated mass hysteria.”

In August another strange thing happened. Above New York City and Boston, witnesses reported seeing thousands of UFOs in the sky. The UFOs were many different colors.

The press reported on the strange sighting. But for balance the press also asked the chairman of the Committee for Total Skepticism about the sightings of thousands of UFOs.

“There is a simple explanation,” said the committee chairman, Paul Davidson. “It was merely a moving dust swarm. What appeared to be UFOs high in the sky were just tiny particles near the eye.”

“Precisely,” said the committee's vice-chairman, William Carter. “Probably the different colors were simply caused by refraction of the dust particles.”

The next month another amazing thing happened. A strange metallic craft descended from the sky and landed in a field in Washington D.C. Strange blue creatures four meters tall were repeatedly seen emerging from the craft, and walking about on top of the craft.

A crowd of television reporters surrounded the craft. Annoyed by the attention the craft was getting, Paul Davidson and William Carter rushed to where the craft had landed. Carter and Davidson grabbed a TV reporter, and asked him to have his camera crew film the pair.

“We will now demonstrate that this so-called extraterrestrial landing is merely a paper-mache illusion or a case of mass hysteria,” said Paul Davidson. “Watch, we will now shoot these so-called extraterrestrials, and no harm will come to us.”

The two took out guns, and began firing at the strange figures on top of the UFO. Soon the UFO fired back a laser-powered heat ray that instantly turned both Davidson and Carter into charred crisp blackened cinders.

Both of the men experienced their souls floating out of their burnt dead bodies. They both experienced the strange wonder of passing through a tunnel at great speeds, moving towards a bright light. After passing through the tunnel, they found themselves in some strange shining realm with magnificent glowing towers taller than any on Earth. Looking at each other, Carter and Davidson could see they now had transparent spirit-bodies. Dead relatives came to greet them, also appearing as transparent figures that moved with a floating, flying motion.

“We must still be back in Washington," said Paul Davidson. "This whole experience must just be a hallucination.” 

“Precisely,” said William Carter. “No doubt we're having one of those cross-infection hallucinations experienced identically by two people.”

Saturday, June 22, 2019

Poll Suggests Very Many Atheists Reject Naturalism

Darwinism is the belief that that all organisms have a common ancestor, and that the world's species arose by purely natural processes, mainly because of random mutations that were favored by “natural selection” (a term that refers merely to the superior reproduction rate of fitter organisms). Nowadays when an advocate of Darwinism hears about objections to Darwinism, he will often suggest that such objections are merely based on religion. This claim has always been very dubious, because it is quite possible to make a very detailed case against the claims of Darwinism without ever stating any religious doctrine. For example, without mentioning any religious doctrine, a writer might discuss the failure of Darwinism to explain the origin of life, the failure of Darwinism to explain the appearance of the useless initial stages of complex biological innovations, the failure of Darwinism to explain the Cambrian Explosion,  and the failure of Darwinism to explain the origin of language. 

Recently a poll appeared profiling the beliefs of the non-religious such as atheists and agnostics. An interesting finding from this "Understanding Unbelief" poll (conducted by some university scientists) is that a significant minority of atheists and agnostics seem to doubt Darwinism

Below is a finding from page 17 of the poll:

Percent agreeing “strongly” or “somewhat” with the statement “Humans have developed over time from simpler, non-human life forms.”

Atheists/Agnostics General Population
Brazil 66 50
China 74 87
Denmark 69 59
Japan 49 68
United Kingdom 74 63
USA 80 49
Average 69 63

The results in the second column are not surprising for the USA. It has been known for a long time that roughly half of the US population rejects the textbook story about the origin of humans. What is surprising here is how the question reveals that Darwinism seems to be doubted by very substantial fractions of atheists and agnostics. It seems that a full 20% of atheists and agnostics in the US do not agree “strongly” or “somewhat” with the claim that “humans have developed over time from simpler, non-human life forms,” and that in the UK about 25% of atheists and agnostics do not agree “strongly” or “somewhat” with that claim. Moreover, in Brazil apparently about one third of atheists and agnostics do not agree “strongly” or “somewhat” with the claim that “humans have developed over time from simpler, non-human life forms,” and in Japan about half of atheists and agnostics do not agree “strongly” or “somewhat” with the claim that “humans have developed over time from simpler, non-human life forms.”

This question is not actually one that exactly measures full belief in Darwinism, because the question says nothing about what caused humans to appear. Let us imagine that the question had been worded to exactly measure belief in Darwinism. Then the question might have been something like: “Do you agree strongly or somewhat with this statement: humans have developed over time from simpler, non-human life forms, purely because of natural factors such as random mutation and natural selection?” Since this question is more specific, asking people to endorse a particular belief about what caused the origin of humans, the percentages of people answering “Yes” would almost certainly have been smaller. What the survey has revealed is that even when they are given a “human origins” statement that says nothing about causes, and matches textbook explanations, a very substantial fraction of atheists and agnostics fail to say they support the statement "strongly" or "somewhat." 

In light of such a survey, you should not believe claims that objections to Darwinism stem purely from religious belief. If that were true, we might have expected 90% or 95% of the atheists or agnostics to agree “strongly” or “somewhat” with the claim that  "humans have developed over time from simpler, non-human life forms,” rather than an average of only 69% of them agreeing "strongly" or "somewhat" with such a statement. 

On page 13 there was a question asking atheists and agnostics whether they believed in a “universal spirit or life force.” In Denmark, China the US, and the UK, the answer was “Yes” for about 18% to 27% of the atheists asked the question, and a similar fraction of agnostics answered “Yes.” 

There is a reason why the result on page 13 should surprise no one. The term “God” is loaded with historical and cultural baggage, and much of that baggage has negative connotations. The term “God” has negative connotations to very many people, but many such people are not hostile to the underlying idea of a supreme mind behind the universe. Use the term “God” in a poll question, and many people will think of things they dislike, like the image of an angry bearded figure on a throne. But many of those same people may respond affirmatively if you ask about the possibility of some Cosmic Mind or Universal Spirit or “intelligent guiding force behind nature.”  For example, in a poll of Danish citizens, 28% said "they believe there is a God," but a separate 47% said "they believe there is some sort of spirit or life force," with only 24% saying, "they do not believe there is any sort of spirit, God or life force." 

Therefore a conversation something like the one below is not one you should ever be surprised to hear.

Joe: Do you believe in God?
Jim: God? Angry old guy on a throne in the clouds? I don't believe in that kind of bull.
Joe: Okay, I got you. But what about some intelligent ordering principle or mind guiding the universe to a purposeful result?
Jim: Well, sure, there's probably something like that.

When do I Google search for the definition of naturalism, the first definition I get is "the philosophical belief that everything arises from natural properties and causes, and supernatural or spiritual explanations are excluded or discounted."  Such a belief is synonymous with materialism. Page 3 of the poll states, "Only minorities of atheists or agnostics in each of our countries appear to be thoroughgoing naturalists."  On page 13 the poll indicates that there is a substantial minority of atheists (about 10% to 30%) who believe in life after death. 

The poll had a pretty good sample size. 900 atheists and agnostics were polled in each of several countries, and in each country 200 of the general population were polled, with those 200 having characteristics matching that in the country as a whole.

Wednesday, June 19, 2019

Blame Mainly Authors for Junk Science (Which Is Everywhere)

There was recently published a remarkable article by Alex Gillis entitled “The Rise of Junk Science.” The story is told in simplistic “good guy/bad guy” terms in which the blame is put on a group of publishers who supposedly are not being restrictive enough in excluding poor-quality scientific papers. The story tells us that in order to make money while incurring very low operating costs, certain publishers of scientific papers seem to be doing very little peer review to exclude bad papers. A remarkable claim is attributed to a professor named Eduardo Franco:

These companies have become so successful, Franco says, that for the first time in history, scientists and scholars worldwide are publishing more fraudulent and flawed studies than legitimate research—maybe ten times more. Approximately 10,000 bogus journals run rackets around the world, with thousands more under investigation, according to Cabell’s International, a publishing-services company. 'We’re publishing mainly noise now,' Franco laments. 'It’s nearly impossible to hear real signals, to discover real findings.' "

I know of no hard facts that substantiate these claims by Franco, which I suspect are exaggerated. I also failed to find any justification in the article that there are great numbers of “bogus journals” that are running “rackets.” The only thing the article describes are scientific journals that publish scientific papers without doing much to exclude bad papers.

Let us imagine that you start an open-access scientific journal with a non-restrictive publication policy. You decide that anyone who writes up a scientific experiment can publish it in your journal. Are you guilty of running a “bogus journal” and running a racket because you do not get scientists to peer-review the work submitted? I think not. You are simply someone who has started a journal with a publication policy that differs from social norms. Of course, if you claim that your journal is peer-reviewed but you do not actually engage in peer-review (by hiring scientists to review submitted articles), that would be bogus, because it would be a misrepresentation.

Peer-review of scientific papers has always been something that is a mixture of something good mixed with something that is very bad. The good done by peer-review is that some bad papers get excluded from publication. But it is not at all true that peer-review is an effective quality control system. One reason is that peer-review does not involve reviewing the source data behind an experiment.

Imagine you submit to a scientific journal a paper describing an experiment involving animals. If your paper is being peer-reviewed, the reviewer does not come over to your laboratory and ask to check the data you used to write up your paper. The peer-reviewer does not ask to see your daily log book or see photographs you took to document the experiment. Instead, the peer-reviewer assumes the honesty of the person writing the paper.

So what types of things are excluded by peer-reviewers? Things like this:
  1. Obvious logical errors or obvious procedural errors that can be detected by reading the paper.
  2. Obvious mathematical errors that can be found in the paper.
  3. Deviations from belief customs of scientists. A paper may be rejected by peer-reviewers mainly because it presents evidence against a cherished belief of scientists, or if the paper seems to have sympathy for some idea that is a taboo in the scientific community.
  4. Papers producing null results, which fail to confirm the hypothesis they were testing. Such papers are very often excluded on the grounds of being uninteresting, and sometimes excluded because a scientist would prefer to believe the hypothesis is correct. 
Because peer-review acts like a censorship system, it does great harm. Peer-review helps to keep scientists in “filter bubbles” in which they only read about results that are consistent with their world views. The scientist reading his peer-reviewed journal and reading only results consistent with a materialist worldview may be like a 1970's Soviet Union citizen reading his daily edition of Pravda, and reading only information compatible with a Marxist-Leninist worldview. The exclusion of null results (experiments that did not confirm the hypothesis tested) is a very great problem that often leads scientists to think certain effects are more common or better-established than they are, or that certain claims are better substantiated than they are. 

And since you can't very effectively police bad scientific papers without doing a detailed audit that asks to look at source data, peer-review doesn't do very much to prevent scientific fraud. A more effective system would be one in which there was no peer-review except for a certain small percentage of experimental papers which would be randomly selected to undergo a thorough audit, with the auditor allowed to conduct detailed interviews with all the experimenters, and with an inspection of the original source data. A scientist would be unlikely to commit fraud if he thought there was a 5% chance his experiment would have to face such a detailed audit.

Peer-review as it has been traditionally practiced is such a mixed bag that is no obvious evil for a scientific journal to dispense with it altogether and allow unrestricted publication for any scientist presenting a paper. That would result in some more bad papers, but also allow the publication of many papers that should have been published but were not published because of being wrongly blocked by a typical peer-review system.

It seems, therefore, that if there are many junk science papers being published, the people we should mainly blame are not publishers failing to uphold dubious peer-review conventions, but instead the scientists who wrote the junk science papers. It's rather silly to be suggesting “there's so much junk science – damn those bad publishers,” when the main person to be blamed for a bad science paper is the author of that paper, not its publisher. 

One big problem with the Gillis article is that it creates a simplistic narrative that may lead you to think that junk science exists almost entirely in junk science journals that do not follow proper peer-review standards. But the truth is that junk science is all over the place.  Very many of the scientific papers published in the most reputable scientific journals are junk science papers. 

There are several reasons why a sizable fraction of the scientific papers published should be called junk science. One reason is that very many scientific papers consist of groundless speculation, flights of fancy in which imaginative guesswork runs wild.  For example, a large fraction of the scientific papers published in cosmology journals, particle physics journals, neuroscience journals and evolutionary biology journals consist of such runaway speculation. 

Another reason is that a sizable fraction of all experimental papers involve sample sizes that are too small. A rule-of-thumb in animal studies is that at least 15 animals should be used in each study group (including the control group) in order for you to have moderately compelling evidence in which there is not a high chance of a false alarm. This guideline is very often ignored in scientific studies that use a much smaller number of animals. In this post I give numerous examples of  memory studies that were guilty of such a problem.

The issue was discussed in a paper in the journal Nature, one entitled Power failure: why small sample size undermines the reliability of neuroscience. The article tells us that neuroscience studies tend to be unreliable because they are using too small a sample size. When there is too small a sample size, there's a too high chance that the effect reported by a study is just a false alarm. 

The paper received widespread attention, but did little or nothing to change practices in neuroscience. A 2017 follow-up paper found that "concerns regarding statistical power in neuroscience have mostly not yet been addressed." Exactly the same problem exists in the field of psychology.  It is interesting that the peer-review process (supposedly designed to produce high-quality papers) totally fails nowadays to prevent the publication of scientific studies that are probably false alarms because a too-small sample size was used. 

An additional reason for junk science in mainstream journals is that a great deal of biomedical research is paid for by pharmaceutical companies trying to drive particular research results (such as one suggesting the effectiveness of the medicine they are selling).  Yet another reason for junk science in mainstream journals is that the modern scientist is indoctrinated in unproven belief dogmas that he is encouraged to support, and he or she often ends up writing dubious papers trying to support these far-fetched ideas.  Such papers may commit any of the sins listed in my post, "The Building Blocks of Bad Science Literature." 

A widely discussed 2005 paper entitled "Why Most Published Research Findings Are False" stated the following:

"Simulations show that for most study designs and settings, it is more likely for a research claim to be false than true. Moreover, for many current scientific fields, claimed research findings may often be simply accurate measures of the prevailing bias."

There are very many junk-science studies in even the best science journals. Scientists know some of the ways in which the amount of junk science papers can be reduced (such as increasing the sample size and statistical power of experimental studies). But thus far there has been little progress in moving towards more rigorous standards that would reduce the number of junk science papers. 

Many science textbooks contain a great deal of junk science, mixed in with factual statements. Since textbooks do little more than summarize what is written in science journals,  a large number of false published research findings will inevitably result in a huge number of false claims being made in science textbooks. 

science textbook

"Junk" means "something of little value," and when I speak of "junk science" here I include any science paper that is of little value, for reasons such as being too speculative or too trivial or because of drawing conclusions or making insinuations that are poorly supported or not likely to be true. 

Most scientific claims must be critically scrutinized, and we must always be asking questions such as, "Do we really have proof for such a thing?" and "Why might they have gone wrong when reaching such a conclusion?" and "What alternate explanations are there for the observations?" We cannot simply trust something because it is published by some publisher with a good reputation. 

Sunday, June 16, 2019

Study Hints Your Brain Isn't Making Your Dreams

There are many problems with neuroscience studies that greatly affect their reliability, and should cause us to believe that a large fraction of them are false alarms. One of the biggest problems is insufficient samples sizes, a problem so bad that it led one neuroscientist to conclude that most published neuroscience studies are false. Another huge problem is the low use of what are called blinding protocols.

Imagine a study involving two different groups of subjects, either humans or animals, who differ in some way. Perhaps one group received some stimulus, and the other did not; or perhaps one group reported some tendency or experience, and the other did not. When a blinding protocol is used, the scientists analyzing these subjects will not know which group the subjects belonged to. So, for example, if 10 test subjects are given a pill, and 10 control subjects are not given the pill, then when scientists are studying data from the subjects they will not know whether the subjects got the pill or did not get the pill.

A blinding protocol such as this can be important for reducing experimental bias. For example, if such a protocol were not used, and you were a scientist asked to compare 10 subjects who you knew were given a pill and 10 subjects who you knew were not given the pill, it would be all too easy for you to show some bias in your analysis caused by your knowledge of whether or not the subjects had been given the pill.

Proper blinding protocols are not often used in neuroscience studies. But recently we had an example of an interesting study that used such a protocol. The study (called the Dream Catcher study) was about whether or not scientists could detect a brain signature of dreaming. Nine subjects went to sleep in a laboratory, each with an EEG reader attached to his or her head. The brain waves of the subjects were recorded, and at random intervals subjects were woken up. The subjects were then asked to recall any dreams they were having when woken up. From such cases a Data Team accumulated 27 cases of dreamless sleep, and 27 cases of dreaming sleep, along with the corresponding EEG readings from the brain.

The EEG readings were then given to some other people in an Analysis Team, consisting of people who did not know whether any particular case they were analyzing was a case of dreaming sleep or a case of dreamless sleep. These “blinded” analysts were asked to predict from the EEG readings whether particular cases were examples of dreaming sleep or dreamless sleep.

The result was a null result. The predictions of the analysts (using the EEG data) were not better than what would be expected by chance. The experiment is consistent with the hypothesis that your brain is not actually the source of your dreams.

A previous study by Tononi and others claimed to find some neural correlate of dreaming. In a science news article, Tononi tried to suggest that the difference was due to “trouble” in the methodology of the “Dream Catcher” study finding no evidence of a neural correlate of dreaming. But such an insinuation does not seem fair. Although it involved only 9 subjects, the “Dream Catcher” study involved 54 different cases, and a sample size of 54 is generally regarded as adequate. The “Dream Catcher” study actually involved a protocol much better than that in the Tononi study, which failed to use blinding.

The Tononi study has one claim of predictive success, but only a very dubious one. In one experiment, 84 times sleeping people (connected to EEG brain wave readers) were awoken based on some criteria in their brain waves that might predict that they were dreaming. The paper tells us that the vast majority of these observational cases were thrown away, leaving only 36 cases that were used to judge predictive success; and in that 36 the prediction was pretty good. But this “picking 36 out of 84” smells like cherry-picking to get the desired predictive success, so it is very unimpressive. Among the reasons for discarding observational cases mentioned in the Tononi study (in the Methods section for Experiment 3) is when "sleep stage could not be confirmed," but that is a most dubious procedure, since the whole idea is to show whether we can tell whether people are dreaming from their brain waves; and all the dreamers had their brain waves continuously monitored.   If there was actually a brain wave signal showing dreaming, there should be no reason to throw out most of the observational cases on the basis that "sleep stage could not be confirmed," since the brain waves in such a case would let you know what the sleep stage was. 

What I would like to see is many more neuroscience experiments using proper blinding protocols. Here is an experiment that neuroscientists have not done (to the best of my knowledge), but should be doing:

  1. Do a brain scan on 20 subjects (called Group A). Tell the subjects to think of absolutely nothing during the brain scan other than the blackness of outer space.
  2. Do a brain scan on 20 other subjects (called Group B). Tell the subjects to do some mental task, such as creating a summary total of the first 20 integers. For example, 1+2=3, 1+2+3=6,1+2+3+4=10, 1+2+3+4+5=15, and so on and so forth until a total for the first 20 integers is reached.
  3. Shuffle the brain scans, and submit them to some other “blinded” scientists who do not know whether the subjects were in Group A or Group B. Ask the scientists to predict whether the people were actively engaging in calculation, or simply thinking of the blackness of space.

I predict that the predictive success would not actually be better than chance. The likely reason is that the human brain is not actually the cause of human thought. No one has a coherent idea as to how neurons could produce thinking or ideas. There are strong reasons for believing that fast accurate complex thought should be impossible for a brain, because of the very high noise levels in a human brain (as discussed here), and because signal transmission should actually be very slow in a brain (for reasons discussed here).

Here is another experiment that neuroscientists have not done (to the best of my knowledge), but should be doing:
  1. Do a brain scan on 20 subjects (called Group A). Tell the subjects to think of absolutely nothing during the brain scan other than the blackness of outer space.
  2. Do a brain scan on 20 other subjects (called Group B). Tell the subjects to do some task involving memory recall, such as remembering all the vacations they have ever had (or trying to recall everyone they can remember with a name beginning with the letter “A,” everyone they can remember with a name beginning with the letter “B,” and so forth).
  3. Shuffle the brain scans, and submit them to some other “blinded” scientists who do not know whether the subjects were in Group A or Group B. Ask the scientists to predict whether the people were actively engaging in memory recall, or simply thinking of the blackness of space.

I predict that the predictive success would not actually be better than chance. The likely reason is that the human brain is not actually the cause of human recall. Given the short lifetime of synapse proteins and other forms of instability in the brain, no one has a coherent idea as to how a brain could store memories lasting for decades, or how a brain could instantly recall memories without any addressing system that might allow such a thing. There are strong reasons for believing that the brain is not the storage place of human memory. 

Studies with the protocol above have not been done (to the best of my knowledge). But scientists have done studies in which people have their brains scanned while the people are thinking or recalling. Such studies show no real evidence of neural correlates of thinking or neural correlates of recall. Typically the change in signal strength from one brain region to another (which is the most important thing to consider) is no greater than 1%, about what we would expect from random variations. Such results (discussed here) are consistent with what we would expect if the brain is not a storage place for memories, and if the brain is not the source of our thoughts.  Memory and thought are very likely aspects of a spiritual aspect of man, something quite distinct from the brain. 

An interesting aspect of dreaming is how we can recall names, locations and even intellectual principles during dreaming, even though we may have never thought of such things in years.  Recently I had a dream in which I recalled the principle that you can compute the price of a bond from its yield, a principle I haven't used, read about or thought about in many years.  Nobody has a coherent detailed explanation as to how such abstract principles could ever be stored as neural states or synapse states, and it is all the more impossible to explain how a sleeping person's brain could recall such a principle.