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- "The origin of the amniotic egg and the amphibian - reptile transition is just another of the major vertebrate divisions for which clearly worked out evolutionary schemes have never been provided. Trying to work out, for example, how the heart and aortic arches of an amphibian could have been gradually converted to the reptilian and mammalian condition raises absolutely horrendous problems....The living world is full of innumerable other systems, particularly among the insects and invertebrates, for which gradual evolutionary explanations have never been provided." -- Michael Denton, MD and biochemistry PhD, "Evolution: A Theory in Crisis," 1986, page 219.
- "Major transitions in biological evolution show the same pattern of sudden emergence of diverse forms at a new level of complexity. The relationships between major groups within an emergent new class of biological entities are hard to decipher and do not seem to fit the tree pattern that, following Darwin's original proposal, remains the dominant description of biological evolution. The cases in point include the origin of complex RNA molecules and protein folds; major groups of viruses; archaea and bacteria, and the principal lineages within each of these prokaryotic domains; eukaryotic supergroups; and animal phyla. In each of these pivotal nexuses in life's history, the principal 'types' seem to appear rapidly and fully equipped with the signature features of the respective new level of biological organization. No intermediate 'grades' or intermediate forms between different types are detectable." -- Biologist Eugene Koonin, "The Biological Big Bang model for the major transitions in evolution" (link).
- "This is the basic story of evolution, as recounted in countless textbooks and pop-science bestsellers. The problem, according to a growing number of scientists, is that it is absurdly crude and misleading." --Stephen Buranyi, science writer, "Do We Need a New Theory of Evolution?" in The Guardian.
- "I may challenge the adherents of the strictly Darwinian view, which we are discussing here, to try to explain the evolution of the following features by accumulation and selection of small mutants: hair in mammals, feathers in birds, segmentation of arthropods and vertebrates, the transformation of gill arches in phylogeny, including the aortic arches, muscles, nerves, etc.; further, teeth, shells of mollusks, ectoskeletons, compound eyes, blood circulation, alternation of generations, statocysts, ambulacral system of echinoderms, pedicellaria of the same, cnidocysts, poison apparatus of snakes, whalebone, and, finally, primary chemical differences like hemoglobin vs. hemocyanin, etc. Corresponding examples from plants could be given." -- Biologist Richard Goldschmidt, "The Material Basis of Evolution," pages 6-7.
- “While scientists are still working out the details of how the eye evolved, we are also still stuck on the question of how intelligence emerges in biology.” -- Scientists Rafael Yuste and Michael Levin, an article in Scientific American.
- "Biological systems have evolved to amazingly complex states, yet we do not understand in general how evolution operates to generate increasing genetic and functional complexity." -- four scientists, "Adaptive ratchets and the evolution of molecular complexity."
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