"DNA as Recipe" Is as False as "DNA as Blueprint"

In 1943 physicist Erwin Schrodinger speculated that the chromosomes of a cell “contain, in some kind of code-script, the entire pattern of the individual’s future development and of its functioning in the mature state.” Within a decade, DNA was discovered. But DNA never was found to be anything like some blueprint or recipe or code-script for making a human being. 

The Cambridge English Dictionary defines a blueprint as "a complete plan that explains how to do or develop something." DNA merely contains very low-level chemical information such as lists of the amino acids that make up the proteins in our bodies. Nowhere in DNA is there any of the following:

1. a specification of the large-scale structure of the human body;
2. a specification of the structure of any of the appendages of the human body such as legs or arms or heads;
3. a specification of any organ system of the human body;
4. a specification of any individual organ of the human body;
5. a specification of any of the 200 types of cells in the human body;
6. a specification of any of the organelles that are the building blocks of cells.

There are several different reasons why we know that DNA has no such things. The first reason is that human DNA has been very thoroughly analyzed through multi-year scientific projects involving very large teams of scientists, such as the Human Genome Project and the ENCODE project, and no such specifications have been found in DNA. For example, no one has found any place in DNA where it specifies that humans have two legs or two arms or one neck or two eyes or two ears or ten fingers. The second reason is that only one type of “language” has ever been found used by DNA, the very low-level “poor-man's language” of the genetic code, allowing nothing to be stated other than low-level chemical information such as the amino acids in proteins. Using this “poor-man's language” capable of only stating amino acids or other equally low-level chemical information, it is absolutely impossible to state things such as a complex three-dimensional structure or the anatomy of the eye or the anatomy of the human reproductive system.

DNA only specifies low-level chemical information

The third reason is that if a human DNA molecule were to contain a specification of a human, should a thing would be a fantastically complex instruction that could only be read and interpreted by something in the human womb capable of reading fantastically complex instructions. But nothing like that exists in the human womb. Blueprints are only useful because they are read by human agents smart enough to execute the complex instructions of the blueprints. If a blueprint existed in DNA, it would be something far more complicated than a blueprint for making a home. Such a thing would require some gigantically sophisticated “DNA blueprint reader” capable of reading and executing enormously complicated instructions. But no such thing exists in the human womb. We therefore absolutely cannot explain how a human progresses from a fertilized ovum to a newly delivered baby by imagining that a DNA blueprint or recipe has been read and followed.

Such facts prove in multiple ways that DNA cannot possibly be a blueprint or a program or a recipe for making a human. DNA actually contains less than 10 percent of what is needed to specify a human. A molecule containing all of the information needed to specify a human being would be more than 10 times larger than a human DNA molecule. What we know about the size of the genomes of different organisms is entirely inconsistent with claims that DNA is some kind of blueprint or recipe for making a human. In terms of total number of base pairs, the DNA of humans is more than ten times smaller than the DNA of many amphibians and flowering plants, as you can see in the visual here. We would expect the opposite to be true if DNA contained a blueprint for making a human.

But for decades, mainstream academia has deceived us about DNA, pushing the phony-baloney idea that DNA is some kind of blueprint or recipe or algorithm or program for making a human. I call this falsehood the Great DNA Myth. 

An example of a Darwinist biologist shamelessly telling this gigantic lie is the utterly deceptive statement made below by French biologist Francois Jacob on page 313 in his 1970 book "The Logic of Life: A History of Heredity":

"The formation of a man from an egg is a marvel of exactitude and precision. How can millions of cells emerge, in specialized lineages, in perfect order in time and space, from a single cell? This baffles the imagination. During embryonic development, the instructions contained in the chromosomes of the egg are gradually translated and executed, determining when and where the thousands of molecular species that constitute the body of an adult are to be formed. The whole plan of growth, the whole series of operations to be carried out, the order and the site of syntheses and their coordination are all written down in the nucleic-acid message." 

This was all a huge fiction, written decades before the Human Genome Project had even started to analyze the contents of DNA. Jacob's ideological motivation in telling this lie is made rather clear by the quotation he gives at the very beginning of this book, where he quotes Diderot as saying this:

"Do you see this egg? With it you can overthrow all the schools of theology, all the churches of the earth." 

The false claim that DNA is a blueprint or recipe for making a human was denounced by Ken Richardson, formerly Senior Lecturer in Human Development at the Open University. In an article in the mainstream Nautilus science site, Richardson stated the following:

"Scientists now understand that the information in the DNA code can only serve as a template for a protein. It cannot possibly serve as instructions for the more complex task of putting the proteins together into a fully functioning being, no more than the characters on a typewriter can produce a story."

But the Great DNA Myth (that DNA is a blueprint or recipe for making a human) continues to be pushed by many, including the journal Science, the official publication of the American Association for the Advancement of Science. In September, 2019 the publication had a “special issue” entitled “Genotype to Phentotype.” The issue was designed to give us the idea that genotypes specify phenotypes, an idea that is dead wrong. The phenotype (or visually observable characteristics of an organism) is not specified by an organism's genotype (its DNA). DNA merely specifies low-level chemical information, not high-level structural information.

On page 1395 we are told a huge untruth by Zahn, Purnell and Ash, who stated, “The DNA within a human cell, known as the genotype, provides a blueprint to direct a host of processes for building an embodied organism.” Here we have the two biggest fables about DNA, the myth that it is a blueprint, and the myth that the passive chemical information repository that is DNA “directs” things, as if it were almost some intelligent agent. The fallacy of using words such as “directs” about DNA is debunked by biologist Richardson in his Nautilus article, and he also debunks the “DNA as blueprint” myth by stating, “there is no prior plan or blueprint for development.” 

Introducing some of the papers in the “special issue,” Zahn, Purnell and Ash state, “We examine cases in which various cells and traits are specified by DNA mutations or epigenetic changes.” But humans have 200 different types of cells, and DNA does not contain a specification of any one of them. The “special issue” has a paper with the misleading title, “Mapping human-cell phenotypes to genotypes with single-cell genomics.” But the paper does not at all describe how any cell phenotypes or structures are specified in DNA genotypes. It merely mentions some cases in which rare DNA mutations can affect a cell to produce a disease.  The paper has a visual which attempts to illustrate the idea of some mapping between genes and cell types, but it's just a speculative "something like this could exist" type of thing; and instead of listing specific genes, the genes listed in the mapping are listed as "Gene 1", "Gene 2", "Gene 3," "Gene 4," and "Gene 5." Such speculative illustrations do not constitute any case of showing that a cell type is specified by DNA or genes. 

At a biology "expert answers" site, we read an expert answer telling us that "DNA does not have instructions for how to build a cell," and also that DNA does not even specify how to make the mere membrane of a cell. DNA does not specify any type of cell, and does not even fully specify the things that are smaller than cells. Cells are built from smaller units called organelles, and even their structures are not specified by DNA. When we look at the lowest level of chemical structure, and look at proteins, we find that even those are not fully specified by DNA. DNA specifies the amino acid sequence of proteins, but not their three dimensional shapes.  The mystery of how proteins acquire such three-dimensional shapes is the unsolved problem of protein folding, which scientists have not solved despite decades of laborious efforts. Claims that the three-dimensional shapes of proteins are simply consequences of their amino acids sequences (listed in DNA) are disproved by the failure of ab initio methods to reliably predict the shapes of proteins from their amino acid sequences, and also by the dependency of a large fraction of protein molecules on other molecules (so-called chaperone molecules) in order to achieve their three-dimensional shapes.  A scientific paper about such ab initio protein structure prediction (which uses only the amino acid sequence) tells us, "Currently, the accuracy of ab initio modeling is low and the success is generally limited to small proteins." 

The Genotype to Phenotype “special issue” also very strangely includes a paper entitled “Microbiomes as source of emergent host phenotypes.” Talk about grasping at straws. Your microbiome is the set of all microbes living inside you, or the total DNA of all the microbes living inside you. You will not solve the problem that DNA does not contain a blueprint or recipe for making a human by trying to look for instructions for making a human inside the DNA of microbes living inside a human. The DNA of such microbes suffers from exactly the same limitations of human DNA, limitations which prevent it from being anything like a blueprint or a recipe for building large three-dimensional structures.

None of the papers in the Genotype to Phenotype “special issue” provide anything that should prevent us from thinking that Zahn, Purnell and Ash were feeding us baloney when they stated, “The DNA within a human cell, known as the genotype, provides a blueprint to direct a host of processes for building an embodied organism.” There is zero evidence that DNA is a blueprint for making a human, and we know of several reasons why it cannot be any such thing.  Given its physical limitations limiting it to listing low-level chemical ingredients, it is utterly impossible that DNA could do any such thing as directing or specifying even a single process, let alone "a host of processes."  The biochemical processes inside organisms are gigantically complex, far too complex to be specified or directed by the kind of minimalist "bare bones" poor-man's language that is the genetic code used by DNA,  capable of listing only sequences of low-level chemicals.  Below we see a description of one of these gigantically complex processes, from a biochemistry textbook. 

Immensely complicated biochemistry of vision

On page 26 of the recent book The Developing Genome, Professor David S. Moore states, "The common belief that there are things inside of us that constitute a set of instructions for building bodies and minds -- things that are analogous to 'blueprints' or 'recipes' -- is undoubtedly false." The same expert (in a paper claiming massive misuse by others of the term "heritability") states, "Our DNA, we now know, does not contain specific blueprint-like instructions about traits." Describing conclusions of biologist Brian Goodwin, the New York Times says, "While genes may help produce the proteins that make the skeleton or the glue, they do not determine the shape and form of an embryo or an organism." Massimo Pigliucci (mainstream author of numerous scientific papers on evolution) has stated  that "old-fashioned metaphors like genetic blueprint and genetic programme are not only woefully inadequate but positively misleading." Neuroscientist Romain Brette states, "The genome does not encode much except for amino acids."

In a 2016 scientific paper, three scientists state the following:

"It is now clear that the genome does not directly program the organism; the computer program metaphor has misled us...The genome does not function as a master plan or computer program for controlling the organism; the genome is the organism's servant, not its master."

Debunking the idea of DNA as a program consisting of algorithms, biologist Denis Noble states the following:

"No complete algorithms can be found in the DNA sequences. What we find is better characterised as a mixture of templates and switches. The ‘templates’ are the triplet sequences that specify the amino acid sequences or the RNA sequences."

In the book Mind in Life by Evan Thompson (published by the Belknap Press of Harvard University Press) we read the following on page 180: "The plain truth is that DNA is not a program for building organisms, as several authors have shown in detail (Keller 2000, Lewontin 1993, Moss 2003)."  Scientist Jean Krivine presents here a very elaborate visual presentation with the title, "Epigenetics, Aging and Symmetry or why DNA is not a program." Scientists Walker and Davies state this in a scientific paper:

"DNA is not a blueprint for an organism; no information is actively processed by DNA alone. Rather, DNA is a passive repository for transcription of stored data into RNA, some (but by no means all) of which goes on to be translated into proteins."

Rejecting the "DNA as blueprint" and "DNA as human specification" ideas, biologist Rupert Sheldrake has written the following:

"DNA only codes for the materials from which the body is constructed: the enzymes, the structural proteins, and so forth. There is no evidence that it also codes for the plan, the form, the morphology of the body."

Geneticist Adam Rutherford states that "DNA is not a blueprint," a statement also made by biochemistry professor Keith Fox.  A press account of the thought of geneticist Sir Alec Jeffreys states, "DNA is not a blueprint, he says."  B.N. Queenan (the Executive Director of Research at the NSF-Simons Center for Mathematical & Statistical Analysis of Biology at Harvard University) tells us this:

"DNA is not a blueprint. A blueprint faithfully maps out each part of an envisioned structure. Unlike a battleship or a building, our bodies and minds are not static structures constructed to specification."

"The genome is not a blueprint," says Kevin Mitchell, a geneticist and neuroscientist at Trinity College Dublin, who adds, "It doesn't encode some specific outcome." "DNA cannot be seen as the 'blueprint' for life," says Antony Jose, associate professor of cell biology and molecular genetics at the University of Maryland, who says. "It is at best an overlapping and potentially scrambled list of ingredients that is used differently by different cells at different times." Sergio Pistoi (a science writer with a PhD in molecular biology) tells us, "DNA is not a blueprint," and tells us, "We do not inherit specific instructions on how to build a cell or an organ." Michael Levin (director of a large biology research lab) states that "genomes are not a blueprint for anatomy," and after referring to a "deep puzzle" of how biological forms arise, he gives this example: "Scientists really don’t know what determines the intricate shape and structure of the flatworm’s head."

Ian Stevenson M.D. cited quite a few biologists pointing out the genes and DNA cannot determine the form of an organism:

"Genes alone - which provide instructions for the production of amino acids and proteins -- cannot explain how the proteins produced by their instructions come to have the shape they develop and, ultimately, determine the form of the organisms where they are. Biologists who have drawn attention to this important gap in our knowledge of form have not been a grouping of mediocrities (Denton, 1986; Goldschmidt, 1952; B. C. Goodwin, 1985, 1988, 1989, 1994; Gottlieb, 1992; Grasse, 1973; E. S. Russell...Sheldrake, 1981; Tauber and Sarkar, 1992; Thompson, 1917/1942)."

Biologist B.C. Goodwin stated this in 1989: "Since genes make molecules, genetics...does not tell us how the molecules are organized into the dynamic, organized process that is the living organism." A paper by Stuart A. Newman (a professor of cell biology and anatomy) discussing at length the work of scientists trying to evoke "self-organization" as an explanation for morphogenesis states that "public lectures by principals of the field contain confidently asserted, but similarly oversimplified or misleading treatments," and says that "these analogies...give the false impression that there has been more progress in understanding embryonic development than there truly has been." Referring to scientists moving from one bunk explanation of morphogenesis to another bunk explanation, the paper concludes by stating, "It would be unfortunate if we find ourselves having emerged from a period of misconceived genetic program metaphors only to land in a brave new world captivated by equally misguided ones about self-organization."

Referring to claims there is a program for building organisms in DNA, biochemist F. M. Harold stated "reflection on the findings with morphologically aberrant mutants suggests that the metaphor of a genetic program is misleading." Referring to  self-organization (a vague phrase sometimes used to try to explain morphogenesis), he says, "self-organization remains nearly as mysterious as it was a century ago, a subject in search of a paradigm." 

Physician James Le Fanu states the following:

"The genome projects were predicated on the reasonable assumption that spelling out the full sequence of genes would reveal the distinctive genetic instructions that determine the diverse forms of life. Biologists were thus understandably disconcerted to discover that precisely the reverse is the case. Contrary to all expectations, there is a near equivalence of 20,000 genes across the vast spectrum of organismic complexity, from a millimetre-long worm to ourselves. It was no less disconcerting to learn that the human genome is virtually interchangeable with that of both the mouse and our primate cousins...There is in short nothing in the genomes of fly and man to explain why the fly has six legs, a pair of wings and a dot-sized brain and that we should have two arms, two legs and a mind capable of comprehending the history of our universe."

The false claim that DNA is a blueprint or recipe for making a human was denounced by Ken Richardson, formerly Senior Lecturer in Human Development at the Open University. In an article in the mainstream Nautilus science site, Richardson stated the following:

"Scientists now understand that the information in the DNA code can only serve as a template for a protein. It cannot possibly serve as instructions for the more complex task of putting the proteins together into a fully functioning being, no more than the characters on a typewriter can produce a story."

Writing in the leading journal Cell, biologists  Marc Kirschner, John Gerhart and Tim Mitchison stated, "The genotype, however deeply we analyze it, cannot be predictive of the actual phenotype, but can only provide knowledge of the universe of possible phenotypes." That's equivalent to saying that DNA does not specify visible biological structures, but merely limits what structure an organism can have (just as a building parts list merely limits what structures can be made from the set of parts). A paper co-authored by a chemistry professor (Jesper Hoffmeyer) tells us this: "Ontogenetic 'information,' whether about the structure of the organism or about its behavior, does not exist as such in the genes or in the environment, but is constructed in a given developmental context, as critically emphasized, for example, by Lewontin (1982) and Oyama (1985)." 

As biologist Steven Rose has stated, "DNA is not a blueprint, and the four dimensions of life (three of space, one of time) cannot be read off from its one-dimensional strand."At the Stack Exchange expert answers site, someone posted a question asking which parts of a genome specify how to make a cell (he wanted to write a program that would sketch out a cell based on DNA inputs).  An unidentified expert stated that it is "not correct" that DNA is a blueprint that describes an organism, and that "DNA is not a blueprint because DNA does not have instructions for how to build a cell." No one contradicted this expert's claim, even though the site allows any of its experts to reply. "DNA is not a blueprint for an organism," states Templeton Prize-winning physicist and astrobiologist P. C. W. Davies. A 2024 article says, "Martínez Arias, 68, argues that the DNA sequence of an individual is not an instruction manual or a construction plan for their body...The Madrid-born biologist argues that there is nothing in the DNA molecule that explains why the heart is located on the left, why there are five fingers on the hand or why twin brothers have different fingerprints."

Two scientists said this:

"We see no valid use for definitions of the genotype and phenotype in terms of blueprints, programs, or

sets of instructions, and their realizations or

manifestation....The program/manifestation metaphor is factually misleading, because it suggests that the genotype uniquely determines an organism’s phenotype. However, as is well known, all

it does is specify an organism’s norm of reaction to environmental conditions (Rieger et al., 1991, Lewontin, 1992)."

When we ponder the vastly dynamic nature of the human organism, we may more fully understand the absurdity of trying to explain human morphogenesis by pushing a myth of "the DNA blueprint is read." Blueprints are used to create static things such as buildings.  But a human organism is gigantically dynamic, with a vast horde of diverse cellular activities occuring in most of our flesh.  Each cell is as complex as a factory, and to specify a human (with 200 cell types) you would need (among other things) not merely to specify the structure of each of those 200 cell types, but an intricate description of the activity and processes within those cells.  Such a specification would be as complex as one that not only specified the physical layout of 200 factories, but also one that specified the dynamics of the manufacturing processes and material movements inside such 200 factories. We can think of all too many reasons why such vast complexities could never be specified by a molecule merely listing low-level chemical ingredients.  

Some concede that DNA is not a blueprint, but then say that DNA is a recipe. It is just as false and misleading to claim that DNA is a recipe as it is to say that DNA is a blueprint.  Let's start with the definition of "recipe." The Cambridge English Dictionary defines "recipe"  as "a set of instructions telling you how to prepare and cook a particular food, including a list of what foods are needed for this," giving no other definition. DNA does not tell us how to prepare and cook a food, so it is absurd to be calling DNA a recipe. 

A recipe is not a mere list of ingredients, but a set of assembly instructions on how to make some edible food using those ingredients -- instructions such as "mix for 2 minutes on medium speed of mixer," "chop up almonds and pour them into mixing bowl," "pour mixture into a cake cooking pan," and "bake for 35 minutes at 375 degrees." DNA specifies chemical ingredients, but does not specify any steps or algorithm for using such ingredients to assemble complex things such as cells or organs or reproductive systems or organisms. So it is false to say that DNA is a recipe, unless you merely say that DNA is a recipe for making the low-level chemical units called polypeptide chains.  Because it contains no high-level assembly instructions, DNA is neither a recipe nor a program for making a human, any organ system of a human, any organ of a human, any appendage of a human, or any cell type of a human. 

The Great DNA Myth that DNA is a blueprint or recipe or program for building organisms is not some careless error comparable to someone clumsily saying that there are only 7 planets in the solar system. The claim that DNA is a blueprint or recipe for building organisms is a falsehood typically told by certain people who need to tell this particular falsehood to defend unbelievable claims they wish to defend.   I will leave for another post a discussion of the ideological motivations for this misinformation that has been peddled for decades by esteemed authorities in academia.  

Postscript: The term "body plan" is a profoundly misleading term that biologists love to use, a term that opens the door to deceptions about DNA. In biology literature the term "body plan" has a very limited meaning, something vastly different from a complete plan for constructing an organism. According to a scientific paper "a body plan is a suite of characters shared by a group of phylogenetically related animals at some point during their development." The wikipedia.org article on "body plan" tells us this: "A body plan, Bauplan (German plural Baupläne), or ground plan is a set of morphological features common to many members of a phylum of animals." 

According to this definition, all chordates (including men, bears, dogs and fish) have the same body plan. So when biologists talk about "the human body plan" they

are merely referring to the common characteristics of all chordates, including men, bears, dogs and fish:  basically just the existence of a backbone and bilateral symmetry (having the same things on both sides of the body).  They are not referring to the structure of the 200 types of cells in the human body, or the structure of internal organs, and are not referring to the dynamic intricacies of human physiology. But anyone hearing the term "body plan" will think the term referred to a complete specification of a human body.  So, most misleadingly, biologists may say that this or that "determines the body plan," when all they mean is the beginning of a bilateral organism with a backbone, something a thousand times simpler than the final product of the internally dynamic and enormously organized human body.  This is as misleading as someone saying that he has built a starship, when he has merely built a boat in the shape of a star.