The
Jurassic Park series of movies has been wildly successful.
When such a movie series is seen by so many people, its underlying
premise can work its way into our minds as a settled fact. In this
case that's a shame, because there are very strong reasons for
suspecting that the underlying premise of the Jurassic Park movies
is not correct. There are very strong reasons for believing that we
will never be able to recreate protoplasmic dinosaurs by discovering
some bit of dinosaur DNA, and then leveraging that to create
dinosaurs.
The
basis premise of Jurassic Park was presented in a cute little
animation near the beginning of the first movie. The animation
depicted an insect that bit a dinosaur, and then got stuck in gooey
amber, while a drop of dinosaur blood was still in its body. The
amber then solidified to rock-like hardness, preserving the drop
of dinosaur blood. The idea was that scientists then extracted the
dinosaur's DNA, which they then used to create a flesh-and-blood
dinosaur.
Such
a scenario has an underlying assumption that was never explicitly
stated in any of the movies: the assumption that the body plan of an
organism is specified in the organism's DNA. Under this assumption,
if we can find the DNA of a dinosaur, then we have all the
information we need to recreate the dinosaur.
The
idea that the body plan of an organism is stored in the DNA of its
cells is a widespread assumption. But there is no proof that this
assumption is correct, and there are very good reasons for believing
that it is not correct.
The
first reason is that the “language”
used by DNA is a minimalist feature-poor language lacking any grammar
or capability for expressing anything like a blueprint, a recipe, a
program or an algorithm for making an organism. The language
used by DNA is pretty much the poorest, most “bare bones” type of
language you can imagine. It's a language unsuitable for purposes
other than stating lists of chemicals.
For
DNA to be able to specify a body plan, the language used by DNA
would have to support either one of these two things: (1) a
three-dimensional specification similar to a blueprint, specifying
how particular parts fit together and are related to each other from
a positional standpoint, or (2) a set of sequential instructions
specifying how to build a three-dimensional structure, something
similar to the complicated assembly instructions that come with
do-it-yourself unit of furniture. To the best of our knowledge the
simplistic little “bare bones” language used by DNA is utterly
incapable of such sophisticated forms of expression.
MINIATURE LANGUAGES | |||
NAME | LIST OF WORDS IN LANGUAGE | WHAT CAN BE SPECIFIED BY LANGUAGE | WHAT CANNOT BE SPECIFIED BY LANGUAGE |
Sandwich Language | Bread, Turkey, Ham, Cheese, Lettuce, Tomato, Onion, Bacon | Various types of sandwiches | Anything that is not a sandwich |
Exercise Language | Jump, Crouch, Stretch, Punch, Lift, Bend, Squat, Spin | Various types of exercises | Anything that is not an exercise |
DNA Language | Alanine,
Asparagine, Aspartic acid, Arginine, Cysteine, Glutamine, Glycine, Glutamic acid, Histidine, Isoleucine, Lysine,Leucine, Phenylalanine, Methionine, Serine, Proline, Tryptophan,Threonine, Tyrosine, Valine |
Polypeptide sequences – a linear sequence of amino acids | Anything that is not a polypeptide sequence, including the 3D shape of a protein, the shape of any body part, the body plan of any organism, or a behavior or instinct. |
One
of the simplest data structures you learn about in computer science
is a stack. A stack is like a stack of cards in which each card has
one particular piece of information. Complex hierarchical data cannot
be represented with so simple an arrangement.
To
get an idea of why DNA cannot store body plans, imagine you have
twenty boxes on a table. Each box has a particular type of card, and
on each card is printed some part of a house. So there's a box full
of cards each showing a single glass pane, and another box full of
cards each showing a brick, and another box full cards each showing a
wood beam, and another box full of cards each showing a tile, and so
forth.
Now
imagine you are trying to create a specification of a very
complicated mansion. But you cannot lay the cards out on the floor.
All you can do is put the cards in a single stack. You would quickly
realize the impossibility of such a task. A one-dimensional thing
such as a stack cannot represent complex three-dimensional
information. For the same reasons, the stack that is the DNA molecule
cannot be storing three-dimensional body plans.
The
second reason for thinking that body plans are not stored in DNA is
that even if DNA somehow did contain the extremely sophisticated
instructions necessary for expressing body plans, there would be
nothing in the human body capable of interpreting such instructions.
It is never sufficient merely to have instructions capable of
specifying some complicated output. You also need to have an
instruction interpreter sophisticated enough to read those
instructions and produce the complicated output. We know of nothing
in the body that could be capable of creating three dimensional body
outputs using any three-dimensional body plans if they happened to
exist in DNA.
The
third reason for thinking that body plans are not stored in DNA is
that we have not discovered evidence that DNA stores either
algorithmic information for constructing a human body, or any type of
three-dimensional blueprint specifying the structure of a human body.
For example, we have particular parts of DNA storing proteins used by
the eye, but no part of DNA that lays out the very complicated
three-dimensional structure of an eye.
A
fourth reason for doubting that body plans are stored in DNA is that
if body plans were stored
in DNA, we should expect that the size of an organism's DNA should be
proportional to the size and complexity of an organism. For the same
reasons that the blueprints of a skyscraper use much more paper than
the blueprints for a house,
under a “DNA has the body plan” assumption we should think that
the human DNA is much bigger than the size of, say, any flowering
plant. But astonishingly, the opposite is true. The chart here
shows the relative size of the DNA in different organisms. We see
that the size of the DNA (in base pairs) in mammals is much smaller
than the size of the DNA of many amphibians and flowering plants. We
see on this logarithmic chart that the DNA of some amphibians and
flowerings plants holds ten times more information than the DNA of
humans. This discrepancy is know as the C-Value Paradox.
A
related comparison is the number of genes in the DNA. According to
this
link, rice has between 32,000 and 50,000 genes, while humans have
only about 20,000 genes. That's the opposite of what we would expect if DNA
stored body plans.
These
reasons powerfully argue that DNA does not store the body plan of a
complex organism such as a human or a dinosaur. On
page 26 of the recent book The
Developing Genome,
Professor David S. Moore states, "The common belief that there
are things inside of us that constitute a set of instructions for
building bodies and minds -- things that are analogous to
"blueprints" or "recipes" -- is undoubtedly
false." Biologist Rupert Sheldrake says this
about this issue:
DNA
only codes for the materials from which the body is constructed: the
enzymes, the structural proteins, and so forth. There is no evidence
that it also codes for the plan, the form, the morphology of the
body.
''A
gene makes a protein and that's about it,'' states biologist Brian
Goodwin. ''It doesn't tell you how proteins interact, how cells and
tissues communicate, how organs come into being, how an immune system
forms, or how evolution works.''
In a 2016 scientific paper, three scientists state the following:
It is now clear that the genome does not directly program the organism; the computer program metaphor has misled us...The genome does not function as a master plan or computer program for controlling the organism; the genome is the organism's servant, not its master.
In a 2016 scientific paper, three scientists state the following:
It is now clear that the genome does not directly program the organism; the computer program metaphor has misled us...The genome does not function as a master plan or computer program for controlling the organism; the genome is the organism's servant, not its master.
The
myth that DNA stores a complete blueprint of an organism is actually
six levels removed from reality. To show that DNA stores a
complete blueprint for an organism, you would have to establish this
chain of assertions:
- You would need to establish that DNA actually specifies the three-dimensional shapes of proteins.
- You would need to establish that DNA specifies a blueprint for particular cells.
- You need need to establish that DNA specifies a blueprint for particular tissues.
- You would need to establish that DNA specifies a blueprint for particular organs.
- You would need to establish that DNA specifies a blueprint for particular organ systems.
- You would need to establish that DNA specifies a blueprint for particular organisms.
None
of these things have been done – not even the simplest one, the
first of these six. Scientists have been trying for decades to solve
what is called the protein folding problem, the problem of how
proteins get their 3D shapes. It has still not been proven that such
shapes are determined solely by the linear sequence of amino acids in
the proteins. DNA does not even seem to specify the 3D shapes of a
protein molecule. How could it, when the impoverished DNA language
doesn't have any capability for stating three-dimensional positions?
If
DNA does not store the body plan of an organism, we will never be
able to resurrect dinosaurs by using some recovered dinosaur DNA. Nor
will it be possible to ever create a flesh-and-blood dinosaur through
any possible artificial manipulations of DNA. We may have great fun
in parks filled with robotic dinosaurs, but they won't be
flesh-and-blood organisms like us.
If you see this, you'll know it's a robot
Whether we will be able to resurrect dinosaurs isn't all that interesting a question. A far more interesting question raised by these questions is the fundamental question: where are the body plans of organisms stored?
The
answer we must give to this question is: we don't know. We have every
reason to suspect that the secrets of life are far deeper than the average
biologist suspects, and that we are far very indeed from uncovering
such secrets.
Imagine
a little child who is given a palm-sized digital device. The child
may make simplistic assumptions about the device, such as the idea
that all of its functionality is contained inside it, and that the
device stores every item that the child sees when she uses the
device. But the truth is vastly more complex. The device is
connecting with a grand mysterious external infrastructure that the
child knows nothing about : the Internet.
Similarly,
life itself may involve a mysterious connection with some grand
cosmic information infrastructure utterly beyond our current
understanding. Somewhere within such an infrastructure may be stored
the body plans of organisms that cannot be expressed by the poor
man's language of DNA, with its impoverished vocabulary of 20 nouns
(all chemicals).
The
absurdity of calling DNA “the secret of life” (as if it had all
the information needed to explain an organism) becomes clear when we
consider that an organism is something vastly more than just a body
plan. Every organism is a continuous symphony of operations needed
to maintain the organism. Just as you don't explain the music coming
from the performance of a symphony by just giving a physical
specification of the musical instruments and an orchestral seating
plan, a body plan would never explain the biology going on inside an
organism. DNA not have the body plan of the organism, nor does it
have the information for the fantastically complicated interactions
needed for the organism to keep living.
Rather than being "the secret of life," DNA must be only one of many secrets of life. Some of the most important of those secrets have not been discovered. We still have not discovered the secret of life that might explain where body plans come from and how they are stored.
Rather than being "the secret of life," DNA must be only one of many secrets of life. Some of the most important of those secrets have not been discovered. We still have not discovered the secret of life that might explain where body plans come from and how they are stored.
No comments:
Post a Comment